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Coccinia grandis
Coccinia grandis' native range extends from Africa to Asia, including India, the Philippines, China, Indonesia, Malaysia, Thailand, Vietnam, eastern Papua New Guinea, and the Northern Territories, Australia. Its documented introduced range includes the Federated States of Micronesia, Fiji, Guam, Saipan, Hawaii, the Marshall Islands, Samoa, Tonga, and Vanuatu.[2] Seeds or fragments of the vine can be relocated and lead to viable offspring. This can occur when humans transport organic debris or equipment containing C. grandis. Once the ivy gourd is established, it is presumably spread by birds, rats, and other mammals. In Hawaii, it has been suggested that the fruit may be dispersed by pigs.[2] Long-distance dispersal is most commonly carried out by humans due to its culinary uses or by mistake.
Medicinal value In traditional medicine, fruits have been used to treat leprosy, fever, asthma, bronchitis and jaundice. The fruit possesses mast cell stabilizing, anti-anaphylactic and antihistaminic potential.[5] Ivy gourd extracts and other forms of the plant can be purchased online and in health food stores. It is claimed that these products help regulate blood sugar levels. There is some research to support that compounds in the plant inhibit the enzyme glucose-6-phosphatase.[6] Glucose-6-phosphatase is one of the key liver enzymes involved in regulating sugar metabolism. Therefore, ivy gourd is sometimes recommended for diabetic patients. Although these claims have not been supported, there currently is a fair amount of research focused on the medicinal properties of this plant focusing on its use as an antioxidant, anti-hypoglycemic agent, immune system modulator, etc.[citation needed] Some countries in Asia like Thailand prepare traditional tonic like drinks for medicinal purposes.