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Brugmansia are large shrubs or small trees, reaching heights of 3–11 m, with tan, slightly rough bark. The leaves are alternate, generally large, 10–30 cm long and 4–18 cm broad, with an entire or coarsely toothed margin, and are covered with fine hairs.
All parts of Brugmansia plants contain dangerous levels of poison and may be fatal if ingested by humans or animals, including livestock and pets. Contact with the eyes can cause pupil diliation or unequal pupil size.